Non limitative list of references (since 2000)
Skin Sensitisation
Lambrechts N, Vanheel H, Nelissen I, Witters H, Van Den Heuvel R, Van Tendeloo V, Schoeters G, Hooyberghs J. Assessment of chemical skin sensitizing potency by an in vitro assay based on human dendritic cells. Tox Sci (2010); 116(1):122–129
Lambrechts N, Hooyberghs J, Vanheel H, De Boever P, Witters H, Van Den Heuvel R, Van Tendeloo V, Nelissen I, Schoeters G. Gene markers in dendritic cells unravel pieces of the skin sensitization puzzle. Toxicol Lett (2010); 196:95–103
Lambrechts N, Verstraelen S, Lodewyckx H, Felicio A, Hooyberghs J, Witters H, Van Tendeloo V, Van Cauwenberge P, Nelissen I, Van Den Heuvel R, Schoeters G. THP-1 monocytes and macrophages: valuable alternatives for CD34+ progenitor-derived dendritic cells to distinguish skin sensitizers from non-sensitizers? Toxicol Appl Pharmacol (2009); 236(2):221-230
Nelissen I, Selderslaghs I, Leppens H, Van Den Heuvel R, Witters H, Verheyen GR, Schoeters G. MUTZ-3-derived dendritic cells as an in vitro alternative model to CD34+ progenitor-derived dendritic cells for testing of chemical sensitizers. Toxicol. In Vitro (2009); 23(8):1477-81
Hooyberghs J, Schoeters E, Lambrechts N, Nelissen I, Witters H, Schoeters G, Van Den Heuvel R. A cell-based in vitro alternative to identify skin sensitizers by gene expression. Toxicol Appl Pharmacol (2008); 231:103–111
Schoeters E, Verheyen GR, Nelissen I, Van Rompay AR, Hooyberghs J, Van Den Heuvel RL, Witters H, Schoeters GE, Van Tendeloo VF, Berneman ZN. Microarray analyses in dendritic cells reveal potential biomarkers for chemical-induced skin sensitization. Mol Immunol (2007); 44 (12):3222-33
Schoeters E, Nuijten JM, Van Den Heuvel R, Nelissen I, Witters H, Schoeters G, Van Tendeloo VF, Berneman ZN, Verheyen G. Gene expression signatures in CD34+-progenitor-derived dendritic cells exposed to the chemical contact allergen nickel sulphate. Toxicol Appl Pharmacol (2006); 216:131-149
Schoeters E, Verheyen G, Van Den Heuvel R, Nelissen I, Witters H, Van Tendeloo VFI, Schoeters G, Berneman ZN. Expression analysis of immune-related genes in CD34+ progenitor-derived dendritic cells after exposure to the chemical contact allergen DNCB. Toxicol in Vitro (2005); 19(7):909-913
Verheyen G, Schoeters E, Nuijten JM, Van Den Heuvel R, Nelissen I, Witters H, Van Tendeloo V, Berneman Z, Schoeters G. Cytokine transcript profiling in CD34+ progenitor derived dendritic cells exposed to contact allergens and irritants. Toxicol Lett (2005); 155:187-194
De Smedt A, Van Den Heuvel R, Van Tendeloo V, Berneman Z, Schoeters G. Capacity of CD34+ progenitor-derived dendritic cells to distinguish between sensitisers and irritants. Toxicol Lett (2005); 156:377-389
De Smedt A, Van Den Heuvel R, Van Tendeloo V, Berneman Z, Schoeters G, Tuschl H. Phenotypic alterations and IL-1b production in CD34+ progenitor- and monocyte – derived dendrtitic cells after exposure to allergens: a comparative analysis. Arch Dermatol Res (2002); 294:109-116
De Smedt A, Van Den Heuvel R, Berneman Z, Schoeters G. Modulation of phenotype , cytokine production and stimulatory function of CD34+ - derived DC by NiCl2 and SDS. Toxicol in Vitro (2001); 15:319-325
Skin irritation & corrosion
Kandárová H, Liebsch M, Spielmann H, Genschow E, Schmidt E, Traue D, Guest R, Whittingham A, Warren N, Gamer AO, Remmele M, Kaufmann T, Wittmer E, Rosdy M, De Wever B. Assessment of the human epidermis model SkinEthic RHE for in vitro skin corrosion testing of chemicals according to new OECD TG 431. Toxicol in Vitro (2006); 20(5):547-559
Kandarova H, Liebsch M, Schmidt E, Genschau E, Traue D, Spielmann H, Meyer K, Steinhoff C, Tornier C, De Wever B, Rosdy M. Assessment of the skin irritation potential of chemicals using the SkinEthic Reconstituted Human Epidermis model and the common skin irritation protocol evaluated in the ECVAM skin irritation validation study. ATLA (2006); 34:393-406
De Wever B, Rosdy M, Goldberg AM. (2004) An optimized in vitro approach to assess skin irritation and phototoxicity of topical vehicles. In Dermatotoxicology, 6th Edition, Chapter 43, p 849-869, Ed. Taylor and Francis
Coquette A, Berna N, Vandenbosch A, Rosdy M, De Wever B, Poumay Y. Analysis of Interleukin-1 (IL-1) and Interleukin-8 (IL-8) expression and release in in vitro Reconstructed Human Epidermis for the Prediction of in vivo skin irritation and/or sensitization. Toxicol in Vitro (2003); 17:311-321
De Wever B, Charbonnier V. Using tissue engineered skin to evaluate the irritation potential of skin care products. Cosmetics & Toiletries (2002); 117(9):28-36
De Wever B, Cappadoro M, Rosdy M. (2000) Prediction of acute and chronic skin irritation using human epidermis reconstituted in vitro in chemically defined medium. Alternative Toxicological Methods for the New Millenium: Science and Application, National Library of Medicine, Bethesda, Maryland, USA
Mucosal irritation
Lenoir J, Adriaens E, Remon JP. New aspects of the Slug Mucosal Irritation (SMI) assay: Predicting nasal stinging, itching and burning sensations. J Appl Tox (accepted October 2010)
De Cock LJ, Lenoir J, De Koker S, Vermeersch V, Skirtach AG, Dubruel P, Adriaens E, Vervaet C, Remon JP, De Geest BG. Mucosal Irritation Potential of Polyelectrolyte Multilayer Capsules. Biomaterials (accepted October 2010)
Bozdag S, Weyenberg W, Adriaens E, Dhondt MM, Vergote V, Vervaet C, De Prijck K, Nelis HJ, De Spiegeleer B, Ludwig A, Remon JP. In vitro evaluation of gentamicin- and vancomycin-containing minitablets as a replacement for fortified eye drops. Drug Dev Ind Pharm (2010); 36(11):1259-70
Adriaens E, Bytheway H, De Wever B, Esrisch E, Guest R, Hansen E, Vanparys P, Schoeters G, Warren N, Weltens R, Whittingham A, Remon J. Successful prevalidation of the Slug Mucosal Irritation test to assess the eye irritation potency of chemicals. Toxicol In Vitro (2008); 22 (5):1285-1296
Adriaens E, Remon JP. Mucosal irritation potential of personal lubricants relates to product osmolality as detected by the slug mucosal irritation assay. Sex Trans Dis (2008); 35(5):512-516
Adriaens E. The Slug Mucosal Irritation assay. National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) available at www.nc3rs.org.uk (Sept 2006)
Dhondt MMM, Adriaens E, Pinceel J, Jordeans K, Backeljau T, Remon JP. Slug species and populations specific effects on the end points of the Slug Mucosal Irritation test. Toxicol in Vitro (2006); 20(4):448-457
Dhondt MMM, Adriaens E, Van Roey J, Remon JP. The Evaluation of the local tolerance of vaginal formulations containing dapivirine using the Slug Mucosal Irritation test and the Rabbit Vaginal irritation test. European Journal of Pharmaceutics and Biopharmaceutics (2005); 60:419-425
Adriaens E, Dhondt MMM, Remon JP. Refinement of the Slug Mucosal Irritation test as an alternative screening test for eye irritation. Toxicol in Vitro (2005); 19(1):79-89
Dhondt MMM, Adriaens E, Remon JP. The Evaluation of the local tolerance of vaginal formulations, with or without Nonoxynol-9, using the Slug Mucosal Irritation test. Sex Trans Dis (2004); 31(4):229-235
Weyenberg W, Vermeire A, Dhondt MMM, Adriaens E, Kestelyn P, Remon JP, Ludwig A. Ocular bioerodible minitablets as strategy for the managementof microbial keratitis. Invest Ophthalmol Vis Sci (2004); 45(9):3229-3233
Adriaens E, Ameye D, Dhondt MMM, Foreman P, Remon JP. Evaluation of the mucosal irritation potency of co-spray dried Amioca/Poly(Acrylic Acid) and Amioca/Carbopol 974P mixtures. J Control Release (2003); 88(3):393-399
Adriaens E, Remon JP. The evaluation of an alternative mucosal irritation test using slugs. Tox Appl Pharm (2002); 182:169-175
Adriaens E, Dierckens K, Bauters TGM, Nelis HJ, Van Goethem F, Vanparys P, Remon JP. The mucosal toxicity of different benzalkonium chloride analogues with an alternative test using slugs. Pharm Res (2001); 18:937-942
Callens C, Adriaens E, Dierckens K, Remon, JP. Toxicological evaluation of a bioadhesive nasal powder containing a starch and carbopol 974 p on rabbit nasal mucosa and slug mucosa. J Contr Rel (2001); 76:81-91
Ceulemans J, Vermeire A, Adriaens E, Remon JP, Ludwig A. Evaluation of a mucoadhesive tablet for ocular use. J Control Release (2001); 77:333-344
Adriaens E, Remon JP. Gastropods as an evaluation tool for screening the irritating potency of absorption enhancers and drugs. Pharm Res (1999); 16:1240-1244
Respiratory sensitization & asthma
Verstraelen S, Nelissen I, Hooyberghs J, Witters H, Schoeters G, Van Cauwenberge P, Van Den Heuvel R. Gene profiles of THP-1 macrophages after in vitro exposure to respiratory (non-)sensitizing chemicals: identification of discriminating genetic markers and pathway analysis. Toxicol in Vitro (2009); 23:1151-1162
Verstraelen S, Nelissen I, Hooyberghs J, Witters H, Schoeters G, Van Cauwenberge P, Van Den Heuvel. Gene profiles of a human bronchial epithelial cell line after in vitro exposure to respiratory (non-)sensitizing chemicals: identification of discriminating genetic markers and pathway analysis. Toxicol (2009); 255: 151-159
Verstraelen S, Nelissen I, Hooyberghs J, Witters H, Schoeters G, Van Cauwenberge P, Van Den Heuvel. Gene profiles of a human alveolar epithelial cell line after in vitro exposure to respiratory (non-)sensitizing chemicals: identification of discriminating genetic markers and pathway analysis. Toxicol Lett (2009), 185: 16-22
Verstraelen S, Wens B, Hooyberghs J, Nelissen I, Witters H, Schoeters G, Van Cauwenberge P, Van Den Heuvel R. Gene expression profiling of in vitro cultured macrophages after exposure to hexamethylene diisocyanate. Toxicol in Vitro (2008); 22:1107-1114
Verstraelen S, Bloemen K, Nelissen I, Witters H, Schoeters G, Van Den Heuvel R. Cell types involved in allergic asthma and their use in in vitro models to assess respiratory sensitization. Toxicol in Vitro (2008); 22(6):1419-1431
Bloemen K, Verstraelen S, Van Den Heuvel R, Witters H, Nelissen I, Schoeters G. The allergic cascade: review of the most important molecules in the asthmatic lung Immunol Lett (2007); 113:6-18
Bloemen K, Lissens G, Desager K, Schoeters G. Determinants of variability of protein content, volume and pH of exhaled breath condensate. Respir Med (2007); 101(6):1331-1337
Bloemen K, Van Den Heuvel R, Govarts E, Hooyberghs J, Nelen V, Witters E, Desager K, Schoeters G. A new approach to study exhaled proteins as potential biomarkers for asthma. Clin Exp Allergy, In press
Eye irritation & corrosion
Van Goethem F, Hansen E, Sysmans M, De Smedt A, Vanparys P, Van Gompel J. Development of a new opacitometer for the bovine corneal opacity and permeability (BCOP) assay. Toxicol in Vitro (2010); 24:1854-1861
Marrec-Fairly M, Van Goethem F, Bessou-Touya S, De Wever B, Le Varlet B, Pfannenbecker U, McNamee P, Alepee N. COLIPA Program for assessing eye irritation: intra and inter laboratory evaluations of the SkinEthic human corneal epithelium (HCE) and direct peptide reactivity (DPRA) assays. The Toxicologist (2010); 254
Seaman CW, Whittingham A, Guest R, Olson MJ, Guerierro FJ, Aliferis M, Adriaens ME, De Wever B. An evaluation of a cultured human corneal epithelial tissue model for the determination of the ocular irritation potential of pharmaceutical process materials. Toxicol In Vitro (2010); 24 (6):1862-1870
McNamee P, De Clerck L, De Smet A, De Wever B, Faller C, Harbell J, Jones P, Marrec-Fairley M, Paper W, Pfannenbecker U, Schröder K, Tailhardat M, Vanden Berghe C, Van Goethem F. Update on the COLIPA research programme for the development of in vitro alternative methods for eye irritation. ALTEX (2007); 14:377-341
Van Goethem F, Adriaens E, Alépee N, Straube F, De Wever B, Cappadoro M, Vanparys P. Prevalidation of a new in vitro reconstructed human cornea model to assess the eye irritation potential of chemicals. Toxicol in Vitro (2006); 20:1-17
3D cell models
Mavon A, Bacqueville D, De Wever B. Reconstructed human skin and skin organ culture models used in cosmetic efficacy testing (2009). Handbook of Cosmetic Science and Technology, 3rd Edition, Ed. Barel, Maibach & Paye, Chapter 33, p 345-355
Barbotteau Y, Gontier E, Barberet P, Cappadoro M, De Wever B, Habchi C, Incerti S, Mavon A, Moretto P, Pouthier T, Smith RW, Ynsa MD. Reconstructed human epidermis: a model to study the barrier function. Nucl Instrum Methods Phys Res B (2005); 231:286-291
Nguyen DH, Beuerman RW, De Wever B, Rosdy M. (2003) Three-dimensional construct of the human corneal epithelium for in vitro toxicology. In Alternative Toxicological Methods, p 147-159, Ed. Harry Salem and Sidney Katz
Bernard X, Barrault C, Deguercy A, De Wever B, Rosdy M. Expression of type 1 5a-reductase and metabolism of testosterone in reconstructed human epidermis (SkinEthic): a new model for screening skin-targeted androgen modulators. Int J Cosm Sci (2000); 22:397-407
Bernard FX, Barrault C, Deguercy A, De Wever B, Rosdy M. Development of a highly sensitive in vitro phototoxicity assay using the SkinEthic reconstructed human epidermis. Cell Biol Toxicol (2000); 16(6):391-400
In vitro test systems
Vandenhove H, Cuypers A, van Hees M, Koppen G, Wannijn J. Oxidative stress reaction induced in beans (Phaseolus vulgaris) following exposure to uranium. Plant Physiol Biochem (2006); 4:795-805
Gabison E, Steinfels-Kohn E, Mourah S, Hoang-Xuan T, Watsky M, De Wever B, Mauviel A, Menashi S. Expression, Regulation and Activity of EMMPRIN in the Human Cornea. Am J Pathol (2005); 166(1): 209-219
Gasel A, Ramphal P, De Wever B, Tornier C, Hosein N, Lee B, Tomic-Canic M, Blumenberg M. Transcriptional profiling of epidermal keratinocytes: comparison of genes expressed in skin, cultured keratinocytes and artificial skin equivalents, using larg DNA microarrays. J Invest Dermatol (2003); 121(6):1459-68
Immunotoxicity / Haematotoxicity
Devos S, Van Den Heuvel R, Hooghe R, Hooghe-Peters E. Limited effect of selected organic pollutants on cytokine production by peripheral blood leukocytes.
European Cytokine Network (2004); 15(2):1-7
Pessina A, Albella B, Bueren J, Brantonm P, Casati S, Gribaldo L, Croera C, Cagliardi G, Foti P, Parchment R, Parent-Massin D, Sibiril Y, Schoeters G, Van Den Heuvel R. Prevalidation of a model for predicting acute neutropenia by colony forming unit granulocyte / macrophage (CFU-GM ) assay. Toxicol in Vitro (2001); 15:729-740
Van den Heuvel R, Leppens H, Schoeters GER. Use of in vitro assays to assess hematotoxic effects of environmental compounds. Cell Biol Toxicol (2001); 17:107-116
Pessina A, Parent-Massin D, Albella B, Van Den Heuvel R, Casati S, Croera C, Malerba I, Sibiril Y, Gomez S, De Smedt A, Gribaldo L. Application of CFU-Mk assay to predict potential thrombocytotoxicity of drugs. Toxicol in Vitro (2009); 23 (1):p 194-200
Genotoxicity
Maes A, Den Hond E, Verschaeve L. Automated analysis of micronuclei binucleated cells. Microscopy & Analysis (2007); 21(1):7-9
Taylor J, Demyttenaere D, Tehrani K, Olave A, Regniers L, Verschaeve L, Maes A, Elgorashi E, van Staden J, De Kimpe N. Genotoxicity of melanoidin fractions derived from a Standard Glucose/Glycine Model. J Agric Food Chem (2004); 52:318-323
Verschaeve L, Kestens V, Taylor JLS, Elgorashi E, Maes A, Van Puyvelde L, De Kimpe N, Van Staden J. Investigation of the antimutagenic effects of some South African medicinal plant extracts. Toxicol in Vitro (2004); 18:29-35
Taylor J, Elgorashi E, Maes A, Van Gorp U, De Kimpe N, Van Staden J, Verschaeve L. Investigating the safety of plants used in South African traditional medicine - testing for genotoxicity in the micronucleus and alkaline commet assay. Environ Mol Mutagen (2003); 42:144-154
Elgorashi E, Taylor J, Maes A, van Staden J, De Kimpe N, Verschaeve L. Screening of medicinal plants used in South African traditional medicine for genotoxic effects. Toxicol lett (2003); 143:195-207
Verheyen G, Pauwels G, Verschaeve L, Schoeters G. Effect of co-exposure of 50 Hz magnetic fields and an aneugen on human lymphocytes, determined by the cytokinesis block micronucleus assays. Bioelectromagn (2003); 24:160-164
Verschaeve L. Genotoxicity studies in groundwater, surface waters and contaminated soil. The Scientific World Journal (2002); 2:1247-1253
Verschaeve L, van der Lelie D, Regniers L, Corbisier P. (2000)
Use of bacterial tests (the VITOTOX genotoxicity test and the BIOMET heavy metal test) to analyze chemicals and environmental samples.
In: Persoone G, Janssen C, De Coen W. p 197-207, ed. New microtests for routine screening and biomonitoring. Kluwer Academic/Plenum Publishers, New York
Maes A, Collier M, Verschaeve L. Cytogenic investigations on microwaves by a 455.7 MHz car phone. Folia Biologica (2000); 46:175-180
Endocrine disruptors
Witters H, Freyberger A, Smits K, Vangenechten C, Lofink W, Weimer M, Bremer S, Ahr PH, Berckmans P. The assessment of estrogenic or anti-estrogenic activity of chemicals by the human stably transfected estrogen sensitive MELN cell line: Results of test performance and transferability. Reprod Toxicol (2010); 30 (1): 60-72
Freyberger A, Witters H, Weimer M, Lofink W, Berckmans P, Ahr HJ. Screening for (anti)androgenic properties using a standard operation protocol based on the human stably transfected androgen sensitive PALM cell line. First steps towards validation. Reprod Toxicol (2010); 30(1): 9-17
Schenk B, Weimer M, Bremer S, van der Burg B, Cortvrindt R, Freyberger A,Lazzari G, Pellizzer C, Piersma A, Schäfer WR, Seiler A, Witters H, Schwarz M. The ReProTect Feasibility Study, a novel comprehensive in vitro approach to detect reproductive toxicants. Reprod Toxicol (2010); 30 (1):200-218
van der Burg B, Winter R, Weimer M, Berckmans P, Suzuki G, Gijsbers L, Jonas A, van der Linden S, Witters H, Aarts J, Legler J, Kopp-Schneider A, Bremer S. Optimization and prevalidation of the in vitro ERalpha CALUX method to test estrogenic and antiestrogenic activity of compounds. Reprod Toxicol (2010); 30 (1):73-80
van der Burg B, Winter R, Man HY, Vangenechten C, Berckmans P, Weimer M, Witters H, van der Linden S. Optimization and prevalidation of the in vitro AR-CALUX method to test androgenic and antiandrogenic activity of compounds. Reprod Toxicol (2010); 30 (1):18-24
Bovee TFH, Bor G, Becue I, Daamen FEJ, van Duursen MBM, Lehmann S, Vollmer G, De Maria R, Fox JE, Witters H, Bernhoeft S, Schramm K, Hoogenboom RLAP, Nielen MWF. Inter-laboratory comparison of a yeast bioassay for the determination of estrogenic activity in biological samples. Analytica Chimica Acta (2009); 637 (1-2):265-272
Tse Sum Bui B, Belmont A-S, Witters H, Haupt K. Molecular recognition of endocrine disruptors by synthetic and estradiol receptors: a comparative study. Analytical and Bioanalytical Chemistry (2008); 390 (8):2081-2088
Berckmans P, Leppens H, Vangenechten C, Witters H. Screening of endocrine disrupting chemicals with MELN cells, an ER-transactivation assay combined with cytotoxicity assessment. Toxicol in Vitro (2007); 21:1262-1267
Christiaens P, Berckmans P, Haelens A, Witters H, Claessens F.
Comparison of different androgen bioassays in the screening for environmental (anti-) androgenic activity. Environ Toxicol Chem (2005); 24:2646-2656
Van den Belt K, Berckmans P, Vangenechten C, Verheyen R, Witters H.
Comparative study on the in vitro/in vivo estrogenic potencies of 17 beta-estradiol, estrone 17 alfa-ethyloestradiol and nonylphenol. Aquat Toxicol (2004); 66:183-195
Van den Belt K, Verheyen R, Witters H. Effects of 17 alpha-ethynyloestradiol in a partial life-cycle test with zebrafish (Danio rerio): effects on growth, gonads, and female reproductive success. Sci Tot Environ (2003); 309:127-137
Van den Belt K, Wester PW, Van de Ven L, Verheyen R, Witters H. Effects of ethynylestradiol on the reproductive physiology in zebrafish (Danio rerio): time-dependency and reversibility. Environm Toxicol Chem (2002); 21(4):767-775
Lange I, Daxenberger A, Schiffer B, Witters H, Dolores I, Meyer HD. Sex hormones originating from different livestock production systems: fate and potential disrupting activity in the environment. Anal Chim Acta (2002); 473:27-37
Van den Belt K, Verheyen R, Witters H. Reproductive effects of ethynylestradiol and 4t-octylphenol on the zebrafish (Danio rerio). Toxicity of cadmium contaminated clay to the zebrafish. Arch Environ Contam Toxicol (2001); 41:458-467
In vitro tests for the evaluation of mixtures (environmental, food or biological samples)
Pfaller T, Colognato R, Nelissen I, Favilli F, Casals E, Ooms D, Leppens H, Ponti J, Stritzinger R, Puntes V, Boraschi D, Duschl A, Oostingh G. The suitability of different cellular in vitro immunotoxicity and genotoxicity methods for the analysis of nanoparticle-induced events. Nanotoxicology (2010); 4(1):52-72
Verstraelen S, Van Den Heuvel R, Nelissen I, Witters H, Verheyen G, Schoeters G. Flow cytometric characterisation of antigen presenting dendritic cells after in vitro exposure to diesel exhaust particles. Toxicol in Vitro (2005); 19:903-907
Schoeters G, Goyvaerts MP, Ooms D, Van Cleuvenbergen R. The evaluation of dioxin and dioxin-like contaminants in selected food samples obtained from the Belgian market: comparison of TEQ measuremements obtained through the CALUX bioassay with congener specific chemical analyses. Chemosphere (2004); 54: 1289-1297
Verheyen G, Nuijten JM, Van Hummelen P, Schoeters G. Microarray analysis of the effect of diesel exhaust particles on in vitro cultured macrophages. Toxicol in Vitro (2004); 18:377-391
Oomen A, Hack A, Minekus M, Zeijdner E, Cornelis C, Schoeters G, Verstraete W, Van de Wiele T, Wragg J, Rompelberg C,Sips A, Van Wijnen J. Comparison of five in vitro models to study the bioaccessibility of soil contaminants. Environm Sci Technol (2002); 36:3326-3334
Don Porto Carero A, Hoet P, Nemery B, Schoeters G. Increased HLA-DR expression after exposure of human monocytic cells to air particulates.
Clin Exp Allergy (2002); 31:296-300
Du Four VA, Janssen CR, Brits E, Van Larebeke N. Genotoxic and mutagenic activity of environmental air samples from different rural, urban and industrial sites in Flanders, Belgium. Mutat Res (2005); 588:106-117
Bierkens J, Brits E, Verschaeve L. Screening methods for genotoxicity in environmental monitoring. Environmental Toxicity testing (2005); 229-256
Brits E, Schoeters G, Verschaeve L. Genotoxicity of PM10 and extracted organics collected in an industrial, urban and rural area in Flanders, Belgium. Environ Res (2004); 96:109-118
Don Porto Carero A, Hoet PHM, Verschaeve L, Schoeters G, Nemery B. Genotoxic effects of carbon black particles, diesel exhaust particles, and urban air particulates and their extracts on a human alveolar epithelial cell line (A549) and a human monocytic cell line (THP-1). Environ Molec Mutagen (2001); 37:157-163
Witters H, Berckmans P, Vangenechten C. Detection of estrogenic activity in Flemish surface waters using and in vitro recombinant assay with yeast cells. Water, Sci Technol (2000); 43(2):117-123
Zebrafish embryo: model for embryotoxicity and developmental neurotoxicity
Selderslaghs IWT, Hooyberghs J, De Coen W, Witters H. Locomotor activity in zebrafish embryos: A new method to assess developmental neurotoxicity. Neurotoxicol Teratol (2010); 32:460-471
Selderslaghs IWT, Van Rompay AR, De Coen W, Witters HE. Development of a screening assay to identify teratogenic and embryotoxic chemicals using the zebrafish embryo. Reprod Toxicol (2009); 28 (3):308-320
Human biomonitoring
Koppen G, Bloemen K, Colles A, Nelen V, Desager K, Schoeters G. Exposure to traffic-related air pollutants in the perinatal period of life in relation to respiratory health in infancy. Crit Rev Environ Sci Technol, In press.
Bloemen K, Koppen G, Govarts E, Colles A, Van Den Heuvel R, Nelen V, Witters E, Desager K, Schoeters G. Application of non-invasive biomarkers in a birth cohort follow-up in relation to respiratory health outcome. Biomarkers, In press.
Den Hond E, Dhooge W, Bruckers L, Schoeters G, Nelen V, van de Mieroop E, Koppen G, Bilau M, Schroijen C, Keune H, Baeyens W, van Larebeke N. Internal exposure to pollutants and sexual maturation in Flemish adolescents. J Expo Sci Environ Epidemiol (2010)
Smolders R, Bartonova A, Boogaard PJ, Dusinska M, Koppen G, Merlo F, Sram RJ, Vineis P, Schoeters G. The use of biomarkers for risk assessment: Reporting from the INTARESE/ENVIRISK Workshop in Prague. Int J Hyg Environ Health (2010); 213(5):395-400
Simsa P, Mihalyi A, Schoeters G, Koppen G, Kyama CM, Den Hond EM, Fülöp V, D'Hooghe TM. Increased exposure to dioxin-like compounds is associated with endometriosis in a case-control study in women. Reprod Biomed Online (2010); 20(5):681-8
Dhoge W, Den Hond E, Koppen G, Bruckers L, Nelen V, Van De Mieroop E, Bilau M, Croes K, Baeyens W, Schoeters G, Van Larebeke N. Internal exposure to pollutants and body size in Flemish adolescents and adults: associations and dose-response relationships. Environ Int (2010); 36(4):330-7
Keune H, Morrens B, Croes K, Colles A, Koppen G, Springael J, Loots I, Van Campenhout K, Chovanova H, Schoeters G, Nelen V, Baeyens W, Van Larebeke N. Opening the research agenda for selection of hot spots for human biomonitoring research in Belgium: a participatory research project. Environ Health (2010); 6:9-33
Smolders R, Alimonti A, Cerna M, Den Hond E, Kristiansen J, Palkovicova L, Ranft U, Seldén AI, Telisman S, Schoeters G. Availability and comparability of human biomonitoring data across Europe: a case-study on blood-lead levels. Sci Total Environ (2010); 408(6):1437-45
Bloemen K, Hooyberghs J, Desager K, Witters E, Schoeters G. (2009) Non-invasive biomarker sampling and analysis of the exhaled breath proteome. Proteomics Clin Appl; 3(4):498-504.
Verhulst SL, Nelen V, Hond ED, Koppen G, Beunckens C, Vael C, Schoeters G, Desager K. Intrauterine Exposure to Environmental Pollutants and Body Mass Index during the First 3 Years of Life. EHP (2009); 117(1):122-6
Den Hond E, Govarts E, Bruckers L, Schoeters G. Determinants of polychlorinated aromatic hydrocarbons in serum in three age classes - Methodological implications for human biomonitoring. Environmental Research (2009); 109:495-502
Croes K, Baeyens W, Bruckers L, Den Hond E, Koppen G, Nelen V, Van de Mieroop E, Keune H, Dhooge W, Schoeters G, Van Larebeke N. Hormone levels and sexual development in Flemish adolescents residing in areas differing in pollution pressure. Int J Hyg Environ Health (2009) ;212(6):612-25
Bilau M, De Henauw S, Schroijen C, Bruckers L, Hond ED, Koppen G, Matthys C, Van De Mieroop E, Keune H, Baeyens W, Nelen V, Van Larebeke N, Willems JL, Schoeters G. The relation between the estimated dietary intake of PCDD/Fs and levels in blood in a Flemish population (50-65 years). Environ Int (2009); 35(1):9-13
Smolders R, Schramm, K, Nickmilder M, Schoeters G. Applicability of non-invasively collected matrices for human biomonitoring. Environmental Health (2009); 8:8
Koppen G, Den Hond E, Nelen V, Van De Mieroop E, Bruckers L, Bilau M, Keune H, Van Larebeke N, Covaci A, Van De Weghe H, Schroijen C, Desager K, Stalpaert M, Baeyens W, Schoeters G. Organochlorine and heavy metals in newborns: results from the Flemish Environment and Health Survey (FLEHS 2002-2006). Environ Int (2009) ;35(7):1015-22
Van Leeuwen DM, Gottschalk RW, Schoeters G, Van Larebeke NA, Nelen V, Baeyens WF, Kleinjans JC, Van Delft JH. Transcriptome analysis in peripheral blood of humans exposed to environmental carcinogens: a promising new biomarker in environmental health studies. EHP (2008); 116(11):1519-25
Keune H, Loots I, Bruckers L, Bilau M, Koppen G, Van Larebeke N, Schoeters G, Nelen V, Bayens W. Monitoring environment, health and perception. An experimental survey on health and environment in Flanders, Belgium. International Journal of Global Environmental Issues, Special Issue on: “Risk Perception and Social Trust” (2008); 8(1/2):90-110
van Leeuwen DM, Gottschalk RW, Schoeters G, van Larebeke NA, Nelen V, Baeyens WF, Kleinjans JC, van Delft JH. Transcriptome analysis in peripheral blood of humans exposed to environmental carcinogens: a promising new biomarker in environmental health studies. EHP (2008); 116(11):1519-25
Cornelis C, Schoeters G, Kellen E, Buntinx F, Zeegers M., Development of a GIS-based indicator for environmental pesticide exposure and its application to a Belgian case-control study on bladder cancer. Int J Hyg Environ Health (2008)
Smolders R, Koppen G, Schoeters G. Translating biomonitoring data into risk management and policy implementation options for a European Network on Human Biomonitoring. Environ Health (2008); 7(1):S2
Bilau M, Matthys C, Baeyens W, Bruckers L, Backer G, Hond E, Keune H, Koppen G, Nelen V, Schoeters G, Van larebeke N, Willems J, De Henauw S. Dietary exposure to dioxin-like compounds in three age groups: Results from the Flemish environment and health study. Chemosphere (2008); 70(4):584-592
Schoeters G, Den Hond E, Dhooghe W, van larebeke N, Leijs M. Endocrine disruptors and abnormalities of puberty development. Basic & Clinical Pharmacology and Toxicology (2008); 102:168-175
Grandjean P, Bellinger D, Bergman A, Cordier S, Davey-Smith G, Eskenazi B, Gee D, Gray K, Hanson M, Van den Hazel P, Heindel J, Heinzow B, Hertz-Picciotto I, Hu H, Huang T, Jensen T, Landrigan P, McMillen I, Murata K, Ritz B, Schoeters G, Skakkebaek N, Skerfving S, Weihe P, The faroes statement: Human health effects of developmental exposure to chemicals in our environment. Basic & Clinical Pharmacology and Toxicology (2008); 102(2):73-75
Ketelslegers HB, Gottschalk RW, Koppen G, Schoeters G, Baeyens WF, van Larebeke NA, van Delft JH, Kleinjans JC. Multiplex genotyping as a biomarker for susceptibility to carcinogenic exposure in the FLEHS biomonitoring study. Cancer Epidemiol Biomarkers(2008); 17(8):1902-12
Schroijen C, Baeyens W, Schoeters G, Den Hond E, Koppen G, Bruckers L, Nelen V, Van De Mieroop E, Bilau M, Covaci A, Keune H, Loots I, Kleinjans J, Dhooge W, Van Larebeke N, Internal exposure to pollutants measured in blood and urine of Flemish adolescents in function of area of residence. Chemosphere (2008); 71: 1317-1325
De Coster S, Koppen G, Bracke M, Schroijen C, Den Hond E, Nelen V, Van de Mieroop E, Bruckers L, Bilau M, Baeyens W, Schoeters G, van Larebeke N. Pollutant effects on genotoxic parameters and tumor-associated protein levels in adults: a cross sectional study. Environ Health (2008); 7:26
Smolders R, Casteleyn L, Joas R, Schoeters G. Human biomonitoring and the Inspire Directive: Spatial Data as Link for Environment and Health Research, Journal Toxicol Environ Health, Part B (2008); 11:646–659
Colles A, Koppen G, Hanot V, Nelen V, Dewolf MC, Noël E, Malisch R, Kotz A, Kypke K, Biot P, Vinkx C, Schoeters G. Fourth WHO-coordinated survey of human milk for persistent organic pollutants (POPs): Belgian results. Chemosphere (2008); 73(6):907-14
Koppen G, Verheyen G, Verschaeve L, Maes A, Van Gorp U, Den Hond E, Nawrot TS, Staessen JA, Roels HA, Vlietinck R, Schoeters G. A battery of DNA effect biomarkers to evaluate environmental exposure of Flemish adolescents. J Appl Toxicol (2007); 27(3):238-246
Maervoet J, Vermeir G, Covaci A, Van Larebeke N, Koppen G, Schoeters G, Nelen V, Baeyens W, Schepens P, Viaene M, Association of thyroid hormone concentrations with levels of organochlorine compounds in cord blood of neonates, EHP (2007); 115 (12):1780-1786
Smolders R, Schoeters G. Identifying opportunities and gaps for establishing an integrated EDR-triad at a European level. Int J Hyg Environ Health (2007); 210(3-4):253-257
Dhooghe W, van Larebeke N, Koppen G, Nelen V, Schoeters G, Vlietinck R, Kaufman JM, Comhaire F, the Flemish Environmental and Health Study Group. Serum dioxin-like activity is associated with reproductive parameters in young men from the feneral Flemish population. EHP (2006); 114, 11:1670-1676
Schoeters G, Den Hond E, Zuurbier M, Naginiene R, Van Den Hazel P, Stilianakis N, Ronchetti R, Koppe J. Cadmium and children: exposure and health effects, Acta Pediatrica (2006); 95(453):50-54
Den Hond E, Schoeters G. Endocrine disrupters and human puberty. Int J Androl (2006); 29(1):264-271
Zuurbier M, Leijs M, Schoeters G, ten Tusscher F, Koppe J. Children's exposure to polybrominated diphenyl ethers. Acta Paediatrica (2006); 95 (453):50-54
van den Hazel P, Zuurbier M, Babisch W, Bartonava A, Bistrup ML, Bolte G, Schoeters G. Today's epidemics in children - possible relations to environmental pollution and suggested preventive measures. Acta Paediatrica (2006); 95(453): 18-25
Van Larebeke N, Bracke M, Nelen V, Koppen G, Schoeters G, Van Loon H, Vlietinck R. Differences in tumor-associated protein levels among middle-age Flemish women in association with area of residence and exposure to pollutants, EHP (2006); 114:887-892
Koppen JG, Bolte G, Bistrup ML, Bartonava A, Busby C, Butter M, Dorfman P, Fucic A, Gee D, van den Hazel P, Howard V, Kohlhuber M, Leijs M, Lundqvist C, Moshammer H, Naginiene R, Ronchetti R, Salines G, Schoeters G, ten Tusscher G. Exposure to multiple environmental agents and their effect. Acta Paediatrica (2006); 95(453):106-113
Raemdonck A, Koppen G, Bilau M, Willems JL. Exposure of maintenance workers to dioxin-like contaminants during the temporary shutdown of a municipal domestic solid waste incinerator: a case series. Arch Environ Occup Health (2006); 61(3):115-21
Ronchetti R, van den Hazel P, Montemitro E, Schoeters G, Wojtek H, Barreto M, Villa M. Lead neurotoxicity in children: is prenatal exposure more important than postnatal exposure? Acta Paediatrica (2006); 95(453):45-49
Lundqvist C, Zuurbier M, Leijs M, Johansson C, Ceccatelli S, Saunders M, Schoeters G, ten Tusscher G, Koppe J. The effects of PCBs and dioxins on child health, Acta Paediatrica (2006); 95 (453):55-64
Van Larebeke N, Birnbaum L, Boogaerts A, Bracke M, Davis D, Demarini D, Hooper K, Huff J, Kleinjans J, Legator M, Schoeters G, Vähäkangas K. Unrecognized or potential risk factors for childhood cancer. Int J Occup Environ Health (2005); 11: 199-201
Van Larebeke N, Koppen G, Nelen V, Schoeters G, Van Loon H, Albering H, Riga L, Vlietinck R, Kleinjans J. Differences in HPRT mutant frequency among middle-aged Flemish women in association with area of residence and blood lead levels. Biomarkers (2004); 9(1):71-84
Van Den Heuvel R, Koppen G, Staessen J, Den Hond E, Verheyen G, Nawrot T, Roels H, Vlietinck R, Schoeters G. Immunologic biomarkers in relation to exposure markers of PCBs and dioxins in Flemish adolescents (Belgium). EHP (2002); 110:595-600
Koppen G, Covaci A, Van Cleuvenbergen R, Schepens P, Winneke G, Nelen V, Van Larebeke N, Vlietinck R, Schoeters G. Persistent organochlorine pollutants in human serum of 50-65 years old women in the Flanders. Environmental and Health Study (FLEHS), Part 1: Concentrations and regional differences. Chemosphere (2002); 48:811-825
Covaci A, Koppen G, Van Cleuvenbergen R, Schepens P, Winneke G, Van Larebeke N, Nelen V, Vlietinck R. Persistent organochlorine pollutants in human serum of 50-65 years old women in the Flanders Environmental and Health Study (FLEHS). Part 2: Correlations among PCBs, PCDD/PCDFs and the use of predictive markers. Chemosphere (2002); 48:827-832
Nawrot TS, Staessen J, Den Hond EM, Koppen G, Schoeters G, Fagard R, Thijs L, Winneke G. Host and environmental Determinants of Polychlorinated Aromatic Hydrocarbons in Serum of Adolescents. EHP (2002); 110(6):583-589
Staessens J, Nawrot T, Den Hond E, Thijs L, Fagard R, Hoppenbrouwers K, Koppen G, Nelen V, Schoeters G, Vanderschueren D, Van Hecke E, Verschaeve L, Vlietinck R, Roels H. Renal function, cytogenetic measurements, and sexual development in adolescents in relation to environmental pollutants: a feasibility study of biomarkers. The Lancet (2001); 357:1660-1669
Nouwen J, Cornelis C, De Fre R, Wevers M, Viaene P, Mensink C, Patyn J, Verschaeve L, Hooghe R, Maes A, Collier M, Schoeters G, VanCleuvenbergen R, Geuzens P. Health risk assessment of dioxin emissions from municipal waste incinerators: the Neerlandquarter (Wilrijk, Belgium). Chemosphere (2001); 44:909-923
Koppen G, Covaic A, Van Cleuvenbergen R, Schepens P, Winneke G, Nelen V, Schoeters G. Comparison of CALUX-TEQ values with PCB and PCDD/F measurements in human serum of the Flanders Environmental and Health Study (FLEHS). Toxicol Lett (2001); 123(1):59-67
Covaci A, Koppen G, Van Cleuvenbergen R, Schepens P, Winneke G, Schoeters G. Persistent organochlorine compounds in human serum of 50-65 years old women living in two regions of Flanders, Belgium. Organohalogen Compounds (2001); 52:265-268
Bierkens J. Applications and pitfalls of stress-protein in biomonitoring. Toxicol (2000); 153:61-72