Non limitative list of references (since 2000)

Sensitisation/Irritation

Bloemen K, Lissens G, Desager K, Schoeters G. Determinants of variability of protein content, volume and pH of exhaled breath condensate. Respir Med 2007;101(6):1331-1337.

K. Bloemen, S. Verstraelen, R. Van Den Heuvel, H. Witters, I. Nelissen, G. Schoeters. The allergic cascade: review of the most important molecules in the asthmatic lung Immunology Letters - 113: 6-18 (2007)

Schoeters E, Verheyen GR, Nelissen I, Van Rompay AR, Hooyberghs J, Van Den Heuvel RL, Witters H, Schoeters GE, Van Tendeloo VF, Berneman ZN. Microarray analyses in dendritic cells reveal potential biomarkers for chemical-induced skin sensitization. Mol Immunol. 2007, 44 (12):3222-33

E. Schoeters, J.M. Nuijten, R. Van Den Heuvel, I. Nelissen, H. Witters, G. Schoeters, V. Van Tendeloo, Z. Berneman, G. Verheyen,  Gene expression signatures in CD34+-progenitor-derived dendritic cells exposed to the chemical contact allergen nickel sulfate, Toxicology and Applied Pharmacology - 216: 131-149 (2006)

F. Van Goethem, E. Adriaens, N. Alépee, F. Straube B. De Wever, M. Cappadoro, , P. VanParys; Prevalidation of a new in vitro reconstructed human cornea model to assess the eye irritation potential of chemicals. Toxicology In Vitro 2O, 1-17, 2006.

Kandárová, H.; Liebsch, M.; Spielmann, H.; Genschow, E.; Schmidt E.; Traue, D.; Guest, R.; Whittingham, A.; Warren, N.; Gamer, A.O.; Remmele, M.; Kaufmann, T.; Wittmer, E.; Rosdy, M.; De Wever, B. Assessment of the human epidermis model SkinEthic RHE™ for in vitro skin corrosion testing of chemicals according to new OECD TG 431to Toxicology In Vitro, 2006;

B Vande Vannet, B De Wever , J-L Hanssens, H Wehrbein, P Bottenberg, Eddie Wisse. Characterization of in vitro reconstituted human oral (RHOE) and gingival epithelial (RHGE) 3D cell cultures. Clinical Oral Investigations, , 2006.

B. Vande Vannet, B. De Wever, M. Borgers, R. Ramaeckers and P. Bottenberg, The evaluation of sodium lauryl sulphate containing toothpaste toxicity on human gingival and oral mucosa: a 3D in vitro model. Clinical Oral Investigations, , 2006.

H. Kandarova, M. Liebsch, E. Schmidt, E Genschau, D. Traue, H. Spielmann, K. Meyer, C. Steinhoff, C. Tornier, B. De Wever and M. Rosdy. Assessment of the skin irritation potential of chemicals using the SkinEthic Reconstituted Human Epidermis model and the common skin irritation protocol evaluated in the ECVAM skin irritation validation study. ATLA 34, 393-406, 2006.

E. Schoeters, G. Verheyen, R. Van Den Heuvel, I. Nelissen, H. Witters, V.F.I. Van Tendeloo, G. Schoeters, Z.N. Berneman. Expression analysis of immune-related genes in CD34+ progenitor-derived dendritic cells after exposure to the chemical contact allergen DNCB, Toxicology in vitro 19(7): 909-913 (2005)

S. Verstraelen, R. Van Den Heuvel, I. Nelissen, H. Witters, G. Verheyen, G. Schoeters. Flow cytometric characterisation of antigen presenting dendritic cells after in vitro exposure to diesel exhaust particles, Toxicology in Vitro 19: 903-907 (2005)

G. Verheyen, E. Schoeters, J.M. Nuijten, R. Van Den Heuvel, I Nelissen, H. Witters, V. Van Tendeloo, Z. Berneman, G. Schoeters. Cytokine transcript profiling in CD34+ progenitor derived dendritic cells exposed to contact allergens and irritants . Toxicology Letters 155: 187-194 (2005)

De Smedt A., R. Van Den Heuvel, V. Van Tendeloo, Z. Berneman, G. Schoeters.Capacity of CD34+ progenitor-derived dendritic cells to distinguish between sensitisers and irritants / Toxicology Letters 156: 377-389 (2005)

G.R. Verheyen, E. Schoeters, J.-M. Nuijten, R.L. Van Den Heuvel, I. Nelissen, H. Witters, V.F.I. Van Tendeloo, Z.N. Berneman, G.E.R. Schoeters Cytokine transcript profiling in CD34+-progenitor derived dendritic cells exposed to contact allergens and irritants . Toxicology Letters, 155, 187-194 (2005)

De Smedt A.,Van den Heuvel R., Van Tendeloo V., Berneman Z., Schoeters G.E.R. , Capacity of CD34+ progenitor-derived dendritic cells to distinguish between sensitizers and irritants. Toxicology Letters 156, 337-389 (2005).

G. Verheyen, I. Nelissen, I. Selderslaghs, E. Schoeters, R. Van Den Heuvel, H. Witters, G. Schoeters. Evaluation of the Mutz-3 cell line as a model system for in vitro sensitization testing /
Toxicology Letters - 158S(S1-S258): S90 (2005)

E. Gabison, E. Steinfels-Kohn, S. Mourah, T.Hoang-Xuan, M. Watsky, B. De Wever, A. Mauviel & S. Menashi. Expression, Regulation and Activity of EMMPRIN in the Human Cornea. American J. of Pathology, 166, 1, 209-219, 2005.

Y. Barbotteau, E. Gontier, P. Barberet, M. Cappadoro, B. De Wever, C. Habchi, S. Incerti A. Mavon, P. Moretto, T. Pouthier, RW. Smith and MD. Ynsa. Reconstructed human epidermis : a model to study the barrier function, , Nucl Instrum Methods Phys Res B., 2005.

B. De Wever, M. Rosdy and A.M. Goldberg. An optimized in vitro approach to assess skin irritation and phototoxicity of topical vehicles. In Dermatotoxicology 6th Edition, Chapter 43, p 849-869, Ed. Taylor and Francis, 2004.

Gene expression in CD34-derived dendritic cells exposed to the chemical contact allergen nickelsulphate / E. Schoeters, G. Verheyen, G. Schoeters, R. Van Den Heuvel, JM Nuijten, Z. Berneman.
Toxicology and Applied Pharmacology - 197 (3):267 (2004)

Phenotype alterations in CD34-derived dendritic cells after exposure to contact allergens and irritants / R.L Van Den Heuvel, A.C.A. De Smedt, G.E.R. Schoeters.
Toxicology Letters 144(1):s29 (2003)

D.H. Nguyen, R.W. Beuerman, B. De Wever and M. Rosdy. Three-dimensional construct of the human corneal epithelium for in vitro toxicology. In: Alternative Toxicological Methods. Eds. Harry Salem and Sidney Katz, CRC Press, 147-159, 2003.

M. Cappadoro, C. Tornier, B. De Wever and M. Rosdy. Strong reproducibility for 50 chemicals tested for their in vitro skin irritation potential on SkinEthic reconstituted human epidermis using Multiple Endpoint Analysis (MEA)., Toxicology Letters, 144, suppl. 1, S46, 2003.

J. Rowlings, M. Cappadoro, B. De Wever, A. Davis, S. Freeman. Results of an in vitro/in vivo skin irritation validation study with topical acne formulations. Toxicology Letters, 144, suppl. 1, S45, 2003.

A. Coquette, N. Berna, A. Vandenbosch, M; Rosdy, B. De Wever and Y. Poumay. Analysis of Interleukin-1 (IL-1) and Interleukin-8 (IL-8) expression and release in in vitro Reconstructed Human Epidermis for the Prediction of in vivo skin irritation and/or sensitization.. Tox. In Vitro 17, 311-321, 2003.

A. Gasel, P. Ramphal, B. De Wever, C. Tornier, N. Hosein, B. Lee, M. Tomic-Canic and M. Blumenberg. Transcriptional profiling of epidermal keratinocytes: comparison of genes expressed in skin, cultured keratinocytes and artificial skin equivalents, using larg DNA microarrays. J. Investigative Dermatology, 121(6):1459-68, 2003.

R. Van Den Heuvel, A. De Smedt, G. Schoeters. Dendritic cell maturation after nickel exposure in vitro is modulated by PCB126 /
Allergy 57:306 (2002)

De Smedt A., Van Den Heuvel R., Van Tendeloo V., Berneman Z., Schoeters G., Tuschl H. Phenotypic alterations and IL-1b production in CD34+ progenitor- and monocyte – derived dendrtitic cells after exposure to allergens: a comparative analysis, Arch. Dermatol. Res. 294, 109-116 (2002)

B. De Wever, M. Cappadoro, and M. Rosdy. Prediction of acute and chronic skin irritation using human epidermis reconstituted in vitro in chemically defined medium. Alternative Toxicological Methods for the New Millenium: Science and Application. National Library of Medicine, Bethesda, Maryland, USA, 2000.

B. De Wever and Véranne Charbonnier.Using tissue engineered skin to evaluate the irritation potential of skin care products. Cosmetics & Toiletries, 117, 9, 28-36, 2002.

De Smedt A., Van Den Heuvel R., Berneman Z., Schoeters G. Modulation of phenotype , cytokine production and stimulatory function of CD34+ - derived DC by NiCl2 and SDS, Toxicology in vitro, 15, 319-325 (2001).

B. DeWever, M. Cappadoro, and M. Rosdy. SkinEthic Laboratories, Nice, France. Prediction of Acute and Chronic Skin Irritation using Human Epidermis Reconstituted in vitro in Chemically Defined Medium. Alternative Toxicological Methods for the New Millenium: Science and Application. National Library of Medecine, Bethesda, Maryland, USA, 2000.

X. Bernard, C. Barrault, A. Deguercy, B. De Wever and M. Rosdy. Expression of type 1 5a-reductase and metabolism of testosterone in reconstructed human epidermis (SkinEthic): a new model for screening skin-targeted androgen modulators. F- Bioalternatives, Gençay, France, SkinEthic Laboratories, Nice, France. International Journal of Cosmetic Science, 22, p. 397-407, 2000.

F-X. Bernard, C. Barrault, A. Deguercy, B. De Wever, M. Rosdy. Development of a highly sensitive in vitro phototoxicity assay using the SkinEthic reconstructed human epidermis. Cell Biology and Toxicology, Vol. 16,6, p.391-400, 2000.

In vitro test systems

H. Vandenhove, A. Cuypers, M. van Hees, G. Koppen, J. Wannijn Oxidative stress reaction induced in beans (Phaseolus vulgaris) following exposure to uranium /.
Plant Physiology and Biochemistry - 4: 795-805 (2006)

E. Schoeters, G. Verheyen, R. Van Den Heuvel, I. Nelissen, H. Witters, V.F.I. Van Tendeloo, G. Schoeters, Z.N. Berneman. Expression analysis of immune-related genes in CD34+ progenitor-derived dendritic cells after exposure to the chemical contact allergen DNCB /
Toxicology in vitro - 19(7):909-913 (2005)

S. Devos, R. Van Den Heuvel, R. Hooghe, E. Hooghe-Peters. Limited effect of selected organic pollutants on cytokine production by peripheral blood leukocytes.
European Cytokine Network 15(2): 1-7 (2004)

Pessina A. albella B., Bueren J., Brantonm P., Casati S., Gribaldo L., Croera C., Cagliardi G. , Foti P., Parchment R., Parent-Massin D., Sibiril Y. Schoeters G., Van Den Heuvel R. Prevalidation of a model for predicting acute neutropenia by colony forming unit granulocyte / macrophage (CFU-GM ) assay., Toxicology in vitro, 15 (2001), 729-740.

De Smedt A.,Van den Heuvel R., Berneman Z., Schoeters G.E.R. Modulation of phenotype , cytokine production and stimulatory function of CD34+ - derived DC by NiCl2 and SDS, Toxicology in vitro, 15, 319-325 (2001).

Van den Heuvel R., Leppens H., Schoeters G.E.R. Use of in vitro assays to assess hematotoxic effects of environmental compounds, Cell Biology and Toxicology, 2001, 17, 107-116.

Koppen G., Covaic A., Van Cleuvenbergen R., Schepens P., Winneke G., Nelen V. Schoeters G. Comparison of CALUX-TEQ values with PCB and PCDD/F measurements in human serum of the Flanders Environmental and Health Study (FLEHS), Toxicology Letters, 123: (1) 59-67 AUG 6 , 2001

A. De Smedt, R. Van Den Heuvel, G. Schoeters. Sensitising capacity of pesticides tested in vitro using CD34+ derived dentritic cell culture / Allergy, Supplement 63 - Volume 55 p. 158 (2000)

A. De Smedt, R. Van Den Heuvel, G. Schoeters. Phenotypic alterations in cord blood CD34+ derived cells: in vitro model for sensitisation? /
Allergy, (supplement 63) vol. 55, p.24 (2000)

Genotoxicity

A. Maes, E. Den Hond, L. Verschaeve.Automated analysis of micronuclei binucleated cells. Microscopy & Analysis - 21(1): 7-9 (2007

G. Verheyen, G. Pauwels, L. Verschaeve, G. Schoeters. Effect of co-exposure of 50 Hz magnetic fields and an aneugen on human lymphocytes, determined by the cytokinesis block micronucleus assays. Bioelectromagnetics 24:160-164 (2003)

Don Porto Carero A., Hoet P.H.M., Verschaeve L., Schoeters G., Nemery B. (2001)
Genotoxic effects of carbon black particles, diesel exhaust particles, and urban air particulates and their extracts on a human alveolar epithelial cell line (A549) and a human monocytic cell line (THP-1)Environ. Molec. Mutagen. 37, 157-163.

Verschaeve L., van der Lelie D., Verschaeve L., Regniers L., Corbisier P. (2000)
Use of bacterial tests (the VITOTOXâ genotoxicity test and the BIOMET heavy metal test) to analyze chemicals and environmental samples. In: Persoone G., Janssen C., De Coen W., eds., New microtests for routine screening and biomonitoring. Kluwer Academic/Plenum Publishers, New York, pp 197-207.

A. Maes, M. Collier, L. Verschaeve. (2000) Cytogenic investigations on microwaves by a 455.7 MHz car phone. Folia Biologica 46, 175-180

Encdocrine disruptors.

Comparative study on the in vitro/in vivo estrogenic potencies of 17 beta-estradiaol, estrone 17 alfa-ethyloestradiol and nonylphenol / K. Van den Belt, P. Berckmans, C. Vangenechten, R. Verheyen, H. Witters.
Aquatic Toxicology 66: 183-195 (2004)

Effects of 17 alpha-ethynyloestradiol in a partial life-cycle test with zebrafish (Danio rerio): effects on growth, gonads, and female reproductive success / K. Van den Belt, R. Verheyen, H. Witters.
Science of the Total Environment 309:127-137 (2003)
Van den Belt K., Wester P.W., Van de Ven L., Verheyen R. and Witters H. (2002). Effects of ethynylestradiol on the reproductive physiology in zebrafish (Danio rerio): time-dependency and reversibility. Environm. Toxicol. Chem. , 21 (4), 767-775

Lange I., Daxenberger A., Schiffer B., Witters H., Dolores I., H.D. Meyer (2002). Sex hormones originating from different livestock production systems: fate and potential disrupting activity in the environment. Analytica Chimica Acta, 473, 27-37

Van den Belt K., Verheyen R. and Witters H. (2001). Reproductive effects of ethynylestradiol and 4t-octylphenol on the zebrafish (Danio rerio). Toxicity of cadmium contaminated clay to the zebrafish . Arch. Environ. Contam. Toxicol. 41, 458-467.

Witters H., Berckmans P., Vangenechten C. (2000). Detection of estrogenic activity in Flemish surface waters using and in vitro recombinant assay with yeast cells. Water, Science Technology, 43 (2),117-123

In vitro tests for the evaluation of environmental and food quality

V.A. Du Four, C.R. Janssen, E. Brits, N. Van Larebeke. Genotoxic and mutagenic activity of environmental air samples from different rural, urban and industrial sites in Flanders, Belgium. Mutation Research - 588:106-117 (2005)

J. Bierkens, E. Brits, L. Verschaeve. Screening methods for genotoxicity in environmental monitoring. Environmental Toxicity testing - 229-256 (2005)
Blackwell publishing CRC, Garsington Road, Oxford OX4 2DQ, UK, 2005

S. Verstraelen, R. Van Den Heuvel, I. Nelissen, H. Witters, G. Verheyen, G. Schoeters. Flow cytometric characterisation of antigen presenting dendritic cells after in vitro exposure to diesel exhaust particles. Toxicology in Vitro - 19: 903-907 (2005)

E. Brits, G. Schoeters, L. Verschaeve Genotoxicity of PM10 and extracted organics collected in an industrial, urban and rural arean in Flanders, Belgium. Environmental Research 96:109-118 (2004)

J. Taylor, J. Demyttenaere, K. Tehrani, A. Olave, L. Regniers, L. Verschaeve, A. Maes, E. Elgorashi, J. van Staden, N. De Kimpe.Genotoxicity of melanoidin fractions derived from a Standard Glucose/Glycine Model. Journal of Agricultural and Food Chemistry 52: 318-323 (2004)

G. Schoeters, MP Goyvaerts, D. Ooms, R. Van Cleuvenbergen. The evaluation of dioxin and dioxin-like contaminants in selected food samples obtained from the Belgian market: comparison of TEQ measuremements obtained through the CALUX bioassay with congener specific chemical analyses. Chemosphere 54, 1289-1297 (2004)

G. Verheyen, J.M. Nuijten, P. Van Hummelen, G. Schoeters. Microarray analysis of the effect of diesel exhaust particles on in vitro cultured macrophages. Toxicology in vitro - 18: 377-391 (2004)

L. Verschaeve, V. Kestens, J.L.S. Taylor, E. Elgorashi, A. Maes, L. Van Puyvelde, N. De Kimpe, J. Van Staden. Investigation of the antimutagenic effects of some South African medicinal plant extracts. Toxicology in vitro 18: 29-35 (2004)

Investigating the safety of plants used in South African traditional medicine - testing for genotoxicity in the micronucleus and alkaline commet assay / J. Taylor, E. Elgorashi, A. Maes, U. Van Gorp, N. De Kimpe, J. Van Staden, L. Verschaeve.
Environmental and Molecular Mutagenesis 42:144-154 (2003)

E. Elgorashi, J. Taylor, A. Maes, J. van Staden, N. De Kimpe, L. Verschaeve. Screening of medicinal plants used in South African traditional medicine for genotoxic effects. Toxicology letters 143:195-207 (2003)

Verschaeve L. (2002) Genotoxicity studies in groundwater, surface waters and contaminated soil. The Scientific World Journal, 2, 1247-1253.

Oomen A., Hack A., Minekus M., Zeijdner E., Cornelis C., Schoeters G., Verstraete W., Van de Wiele T., Wragg J., Rompelberg C.,Sips A., Van Wijnen J., Comparison of five in vitro models to study the bioaccessibility of soil contaminants. Environm. Sci. Technology , 36, 3326-3334 (2002).

L. Verschaeve Genotoxicitiy studies in groundwater, surface waters and contaminated soil. The Scientific World Journal 2:1247-1253 (2002)

A. Don Porto Carero, P. Hoet, B. Nemery, G. Schoeters. Increased HLA-DR expression after exposure of human monocytic cells to air particulates.
Clinical and Experimental Allergy 31:296-300 (2002)

Rosette Van Den Heuvel, H. Leppens, G. Schoeters. Use of in vitro assays to assess haematotoxicity of environmental compounds /
Cell Biology and Toxicology 17: 107-116

A. Don Porto Carero, P. Hoet, L. Verschaeve, G. Schoeters, B. Nemery. Genotoxic effects of carbon black particles, diesel exhaust particles and urban air particulates and their extracts on a human alveolar epithelial cell line (A549) and a human monocytic cell line (THP-1) /
Environmental and Molecular Mutagenesis, 37:155-163 (2001)

J. Bierkens (2000) Applications and pitfalls of stress-protein in biomonitoring. Toxicology, 153, 61-72 (2000)

Human biomonitoring

G. Koppen, G. Verheyen, L. Verschaeve, A. Maes, U. Van Gorp, E. Den Hond, T.S. Nawrot, J.A. Staessen, H.A. Roels, R. Vlietinck, G. Schoeters.A battery of DNA effect biomarkers to evaluate environmental exposure of Flemish adolescents. Journal of Applied Toxicology - 27(3): 238-246 (2007)

E. Den Hond, G. Schoeters.Endocrine disrupters and human puberty. International Journal of Andrology - 29(1):264-271 (2006)

N. Van Larebeke, G. Koppen, V. Nelen, G. Schoeters, H. Van Loon, H. Albering, L. Riga, R. Vlietinck, J. Kleinjans. .Differences in HPRT mutant frequency among middle-aged Flemish women in association with area of residence and blood lead levels. Biomarkers 9(1): 71-84 (2004)

R. Van Den Heuvel, G. Koppen, J. Staessen, E. Den Hond, G. Verheyen, T. Nawrot, H. Roels, R. Vlietinck, G. Schoeters. Immunologic biomarkers in relation to exposure markers of PCBs and dioxins in Flemish adolescents (Belgium). Environmental Health Perspectives - 110:595-600 (2002)

G. Koppen, A. Covaci, R. Van Cleuvenbergen, P. Schepens, G. Winneke, V. Nelen, N. Van Larebeke, R. Vlietinck, G. Schoeters. Persistent organochlorine pollutants in human serum of 50-65 years old women in the Flanders. Environmental and Health Study (FLEHS), Part 1: Concentrations and regional differences. Chemosphere 48:811-825 (2002)

A. Covaci, G. Koppen, R. Van Cleuvenbergen, P. Schepens, G. Winneke, N. Van Larebeke, V. Nelen, R. Vlietinck. Persistent organochlorine pollutants in human serum of 50-65 years old women in the Flanders Environmental and Health Study (FLEHS). Part 2: Correlations among PCBs, PCDD/PCDFs and the use of predictive markers . Chemosphere 48:827-832 (2002)

T.S. Nawrot, J. Staessen, E.M. Den Hond, G. Koppen, G. Schoeters, R. Fagard, L. Thijs, G. Winneke Host and environmental Determinants of Polychlorinated Aromatic Hydrocarbons in Serum of Adolescents. Environmental Health Perspectives 110 (6): 583-589 JUN 2002

J. Staessens, T. Nawrot, E. Den Hond, L. Thijs, R. Fagard, K. Hoppenbrouwers, G. Koppen, V. Nelen, G. Schoeters, D. Vanderschueren, E. Van Hecke, L. Verschaeve, R. Vlietinck, H. Roels. Renal function, cytogenetic measurements, and sexual development in adolescents in relation to environmental pollutants: a feasibility study of biomarkers . The Lancet 357:1660-1669 (2001)

G. Koppen, A. Covaci, R. Van Cleuvenbergen, P. Schepens, G. Winneke, V. Nelen, A. Brouwer, G. Schoeters. Comparison of CALUX-TEQ values with PCB and PCDD/PCDF measurements in human serum of the Flanders Environmental and Health Study (FLEHS). Toxicology Letters 123(1): 59-67 (2001)

A. Covaci, G. Koppen, R. Van Cleuvenbergen, P. Schepens, G. Winneke, G. Schoeters. Persistent organochlorine compounds in human serum of 50-65 years old women living in two regions of Flanders, Belgium. Organohalogen Compounds 52:265-268 (2001)