International Congress
i-SUP2008
Innovative Sustainable Production 2008
Bruges, Belgium, April 22-25 2008

Scientific program
Conference 5
Environment, Health and Safety testing
Alternative testing, the future for Safety testing

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• Theme 1: Targeted toxicity testing
  • Recent Developments in the Colipa PT-SCAAT Eye Programme for the Development of In Vitro Alternatives
    Pauline McNamee (Procter&Gamble, Surrey, United Kingdom)
  • Different applications of the Slug Mucosal Irritation test in pharmaceutical preclinical drug development
    Els Adriaens (University of Ghent, Belgium)
  • MucilAir: a Novel Human 3D Airway Epithelium Model for Long term Toxicity Testing
    Samuel Constant (Epithelix Sàrl, Switserland)
  • A cell-based in vitro alternative to identify skin sensitizers by gene expression
    Jef Hooyberghs (CARDAM-VITO, Belgium)
  • The use of the reconstructed human EPISKIN^TM for the in vitro assessment of tolerance of chemicals
    Roland Roguet (L’OREAL, France)
  • In vitro assays for endocrine disruptors: test performance and steps to validation
    Hilda Witters (CARDAM-VITO, Belgium)
  • Achieving the goals of toxicity testing in the 21^st century: The TestSmart Developmental Neurotoxicology Testing Programme
    Joe Bressler (Krieger Institute Baltimore (USA)
  • Histone deacetylase inhibitors as new tools to generate metabolic competent long-term cultures of primary hepatocytes
    Tamara Vanhaecke (VUB, Brussels, Belgium)
  • INVITROM - The Dutch-Belgian Society for In vitro methods
    Bas Blaauboer  (IRAS, University of Utrecht, The Netherlands)
  • Alternatives for predictive toxicology in drug development: nice to have or added value?
    Philippe Vanparys (CARDAM, Belgium)
• Theme 2: Implemented test strategies in pharmaceutical, cosmetic and chemical product safety assessment
  • The applicability of in vitro projects for product safety assessment: experiences of the in vitro industrial platform IVTIP
    Cyrille Krull (IVTIP, The Netherlands)
  • Risk assessment: does it need redefinition?
    Bas Blaauboer (IRAS, Utrecht University, The Netherlands)
  • Progress towards novel testing strategies for in vitro assessment of allergens
    Erwin Roggen (Novozymes, Denmark)
• Theme 3: The regulatory Arena: challenges in method acceptance
  • How good are validated methods to predict toxicity of different substances and products?
    Vera Rogiers (VUB - Brussels, Belgium)
  • Current Status Of A Novel Genotoxicity Assay Using A Three-Dimensional Human Skin Model, EpiDermTM
    Rodger Curren (Institute for in vitro Science, Gaithersburg, USA)
  • “Scientifically validated for a specific purpose” should be the end - not the beginning - of the road to regulatory acceptance
    Manfred Liebsch BfR  (Federal Institute for Risk Assessment- Berlin Germany)
  • Regulatory acceptance and implementation of 3R approaches. Activities of the European Partnership for Alternative Approaches to Animal Testing (EPAA)
    Julia  Scheel (Human Safety Assessment - HENKEL (Germany))
  • Current state-of-the-art of genomics in toxicology
    Paul Van Hummelen (VIB - KULeuven, Belgium)
  • In vitro mechanistic toxicology: what can it offer to ecotoxicology?
    Ingrid Nobels (University of Antwerp, Belgium)
• Theme 4: Industrial Centres of Excellence in in vitro services: Who does what?
  • The Centre for Advanced Research and Development of Alternative Methods (CARDAM): a new platform on alternative toxicology testing to meet the needs of industry and legislation
    Bart de Wever (CARDAM-VITO, Belgium)
  • Alternative Methods for Safety Testing of Chemicals - Activities of Industry
    M. Willuhn (LRI - CEFIC,  Brussels,  Belgium)
  • EggCentris, Centre of excellence for reproductive function testing, focuses on innovative in vitro bioassays
    Rita Cortvrindt (Eggcentris Belgium)
  • How a Non-profit Institute successfully combines in vitro testing services with an education program
    Rodger Curren (Institute for in vitro Science, Gaithersburg, USA)
  • In Vitro Testing in Contract Research: A Valid Alternative?
    Robert Guest (Saphefarm,  UK)